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ADOLESCENT TYPE 1 DIABETES CARDIO-RENAL INTERVENTION TRIAL

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Background to AdDIT

Oxford and Cambridge

Childhood and Young Adult Type 1 Diabetes Studies

ORPS, NFS, UK GRID, AdDIT

The history of studies on childhood Type 1 diabetes and its complications in Oxford & Cambridge.

Altogether over 12,500 young people with Type 1 diabetes gave their time and effort to these pivotal studies, organised from Oxford and Cambridge over the last 20 years, which have contributed so much to our understanding of Type 1 diabetes and its complications.

Summary of main findings of these studies:

ORPS: The importance of looking at albumin levels in the urine, particularly during puberty, to determine future risk for kidney and heart complications in young people with Type 1 diabetes.

NFS: How a family history of high blood pressure, high lipids, heart disease, could influence risk for complications in young people with Type 1 diabetes.

The UK GRID: genetic studies were pivotal in determining genes for risk of type 1 diabetes and are now making a major contribution to understanding the genetic contribution to diabetes complications.

AdDIT: The identification of young people with Type 1 diabetes, at high risk for complications in ORPS and NFS, allowed us to focus intervention studies using statins and ACE inhibitors to those most at risk. The results of those studies, which were published last year, and new analyses, which will soon be published, emphasise the importance of early increases in albumin levels in the urine during puberty in determining future risk of vascular complications.

You have helped advance our understanding of Type 1 Diabetes! Thank you for all your support.

Why are we contacting ORPS, NFS & GRID participants now?

To thank you for:

  • Your help which has made an enormous contribution to Type 1 diabetes research.
  • Agreeing to us keeping in touch, to update you on progress of our research and informing you about future projects.

 

To let you know:

  • That your contribution is still relevant to our future understanding of diabetes and its complications.
  • The DNA that you provided is still helping us understand how genes predispose to diabetes and its complications.
  • You are a unique cohort and we believe we can further explore how markers of risk during puberty could be applied to early interventional and preventative strategies.

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Background Publications

  • The Oxford Regional Prospective Study, (ORPS) Publications
  • The Nephropathy Family Study, (NFS) Publications
  • The UK Genetic Resource Investigating Diabetes, (UK GRID)

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  • How we did it
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  • Co-ordinating Centres
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  • AdDIT Publications
  • Background to AdDIT

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